Have you read the I2C tutorial? I had to read it a few times until it made sense...
MORE INFORMATION ON APPLICATION PLEASE - it's impossible to advise, if we don't know what you are trying to do with your I2C connections and configuration.
When it comes to talking to different PICAXE chips in the same system, I tend to just use good 'ole serial at about 2400 buad is normally quick enough, unless you are moving heaps of data...
I2C tutorial PDF is here:
http://www.picaxe.com/docs/axe110_i2c.pdf