Probably nothing significant?
Probably. I don't actually know.
There will be a few microsecond's more in writing two bytes to memory rather than one, but there may be a few microseconds less in deciding to write two bytes rather than one, even if longer it's still only a few microseconds.
I don't know because I've never really considered it worthwhile to find out. It's likely such an insignificant difference that it never really matters.
There may be some cases such as writing data in a loop where it might seem to matter more, but any saving would likely still be a very small amount compared to the rest of the loop's execution time.
For streaming data into memory; @ptrInc or @bPtrInc are probably going to be used anyway. The gain there is it's short and simple and has a fast implied increment.
Not having enough variables when using all words is the main reason I'd not do that.